If you’ve been struggling with hormone imbalances, low energy, fertility issues, or mood swings—and feel like you’re doing everything right—you might want to learn about something called MTHFR.

This gene variation (pronounced “M-th-f-r”) is more common than you’d think, and it plays a surprisingly big role in hormone regulation, detoxification, mental health, and fertility. So let’s break it down.

What Is the MTHFR Gene?

MTHFR stands for methylenetetrahydrofolate reductase—a gene that gives instructions for making an enzyme crucial in a process called methylation.

Methylation is essential for:

• Activating B vitamins (especially folate and B12)

• Detoxifying excess hormones like estrogen

• Regulating inflammation

• Producing neurotransmitters like serotonin and dopamine

• Repairing DNA and supporting cellular function

If you have a mutation or variation in the MTHFR gene, your body may not perform methylation efficiently. This can affect your ability to detox, process nutrients, and maintain hormone balance.

Why MTHFR Matters for Women’s Hormones

Women with an MTHFR mutation may experience:

• Estrogen dominance due to poor detoxification

• PMS, heavy or irregular periods

• Anxiety, mood swings, or postpartum depression

• Difficulty conceiving or increased miscarriage risk

• Low energy and poor resilience to stress

These symptoms can appear subtly—like low motivation, skin changes, or poor sleep—or more dramatically, such as fertility struggles or chronic hormone imbalances.

How Do You Know If You Have an MTHFR Mutation?

It’s more common than many realize—studies suggest that up to 40–60% of the population carries some form of MTHFR variation.

You can test for it using:

• 23andMe or AncestryDNA (analyze raw data through a tool like Genetic Genie or SelfDecode)

• At-home testing kits from companies like Everlywell or MyHappyGenes

• Functional or integrative healthcare providers who offer advanced methylation testing

The two most commonly tested variants are C677T and A1298C.

How to Care for Yourself If You Have It

If you do have an MTHFR variation, the good news is: you can support your body effectively through targeted nutrition and lifestyle habits.

1. Use methylated B vitamins

Standard folic acid and B12 may be difficult for your body to process. Look for:

• Methylfolate (L-5-MTHF)

• Methylcobalamin (B12)

• P-5-P (activated B6)

Ladywell’s Daily Hormone Balance is formulated with methylated, bioavailable B vitamins to bypass the conversion step and work with your body’s needs.

2. Support detox and liver function

Estrogen clearance relies on methylation and liver support. Key strategies include:

• Eating cruciferous vegetables (broccoli, kale, Brussels sprouts)

• Staying hydrated and eating plenty of fiber

• Using gentle liver-supportive herbs (like milk thistle and dandelion)

Daily Hormone Balance contains liver-supportive ingredients and antioxidant botanicals to help facilitate gentle hormone detox.

3. Reduce stress and inflammation

Stress drains your body’s methylation capacity. Support your nervous system with:

• Sleep and recovery

• Mindful movement

• Adaptogenic herbs like ashwagandha, reishi, or holy basil

Ladywell’s formulas include these stress-supporting adaptogens to help restore calm and hormonal resilience.

4. Avoid synthetic folic acid

Folic acid, the synthetic version of folate, is not well tolerated by people with MTHFR and can build up unmetabolized in the bloodstream. Always look for supplements with methylfolate instead.

All Ladywell products are free from synthetic folic acid and formulated with activated forms your body can use safely and effectively. Ladywell’s Prenatal Multivitamin is great for women trying to conceive, pregnant or postpartum who have the MTHFR gene variation as it uses bioactive L-5-MTHF, the methylated form your body can absorb.

5. Prioritize gut health

A healthy gut is essential for metabolizing hormones, supporting detox, and reducing inflammation—especially when methylation is sluggish. Focus on:

• Whole, fiber-rich foods

• Probiotic-rich fermented foods

• Reducing processed and inflammatory ingredients

Ladywell’s focus on bioavailable nutrients and hormone-supportive herbs makes it a great complement to a gut-supportive lifestyle.

The Bottom Line

If you have an MTHFR mutation, it’s not a limitation—it’s valuable insight. When you understand how your body processes nutrients and hormones, you can give it the tools it actually needs to thrive.

At Ladywell, we believe in making hormone health simple, science-backed, and effective. That’s why our supplements are designed with methylated B vitamins, adaptogens, and hormone-friendly nutrients that work in harmony with your body—especially if you’re navigating MTHFR, hormone imbalances, or fertility challenges.

Recommended Ladywell Support for MTHFR

• Daily Hormone Balance Capsules: For mood, energy, skin, and hormonal regularity—made with methylated B vitamins and detox support

• Daily Hormone Balance Powder: A powder version of this best-seller
  
  

• Fertility + Egg Health: Focused support for reproductive health, egg quality, and proper folate metabolism

• Prenatal Multivitamin: Essential nutrients to support you and your baby before, during and after pregnancy with natural nausea support
  

• Magnesium Balance: A topical magnesium spray to support stress resilience, sleep, and inflammation—especially helpful for those with detox or hormonal load

• Creatine Pearl Complex: This triple-active blend of pure creatine monohydrate, grass-fed collagen, and mineral-rich pearl powder is designed to support your strength, skin, and sharpness. Unflavored and easy to mix in any liquid.

Disclaimer

The information provided in this blog is for educational purposes only and is not intended as a substitute for professional medical advice. Always consult a qualified healthcare provider before making any changes to your health regimen, especially if you are pregnant, nursing, or taking any medications.